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Stem cells

Subclone wars

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Pluripotent stem cells, which give rise to every cell type, can acquire cancer-causing genetic mutations when grown in vitro. This finding has implications for the use of pluripotent cells in basic research and in the clinic. See Letter p.229

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Figure 1: The changing profile of human embryonic stem cells (hESCs).

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Stephen Chanock

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  1. Stephen Chanock
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Correspondence to Stephen Chanock.

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Chanock, S. Subclone wars. Nature 545, 160–161 (2017). https://doi.org/10.1038/nature22490

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