Ultraviolet light can damage DNA, triggering a general shutdown of gene transcription — yet some genes are activated by UV light. An investigation of this counter-intuitive behaviour reveals a surprising gene-regulation mechanism.
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Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K. & Linn, S. Annu. Rev. Biochem. 73, 39–85 (2004).
Hanawalt, P. C. DNA Repair 36, 2–7 (2015).
Williamson, L. Cell 168, 843–855 (2017).
Herrlich, P., Ponta, H. & Rahmsdorf, H. J. Rev. Physiol. Biochem. Pharmacol. 119, 187–223 (1992).
Spivak, G. DNA Repair 36, 13–18 (2015).
Mullenders, L. DNA Repair 36, 28–35 (2015).
McKay, B. C. et al. Proc. Natl Acad. Sci. USA 101, 6582–6586 (2004).
Boeing, S. et al. Cell Rep. 15, 1597–1610 (2016).
Saldi, T., Cortazar, M. A., Sheridan, R. M. & Bentley, D. L. J. Mol. Biol. 428, 2623–2635 (2016).
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Conconi, A., Bell, B. The long and short of a DNA-damage response. Nature 545, 165–166 (2017). https://doi.org/10.1038/nature22488
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DOI: https://doi.org/10.1038/nature22488
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