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Effects of a ketamine metabolite on synaptic NMDAR function

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Figure 1: (2R,6R)-HNK blocks NMDAR-mEPSCs and decreases eEF2 phosphorylation in hippocampal neurons.
Figure 2: (2R,6R)-HNK acts as open channel NMDAR blocker.

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Authors and Affiliations

  1. Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9111, Texas, USA

    Kanzo Suzuki, Elena Nosyreva, Ege T. Kavalali & Lisa M. Monteggia

  2. Biopharmaceutical Product Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9111, Texas, USA

    Kevin W. Hunt

Authors
  1. Kanzo Suzuki
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  2. Elena Nosyreva
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  3. Kevin W. Hunt
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  4. Ege T. Kavalali
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  5. Lisa M. Monteggia
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Correspondence to Lisa M. Monteggia.

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Suzuki, K., Nosyreva, E., Hunt, K. et al. Effects of a ketamine metabolite on synaptic NMDAR function. Nature 546, E1–E3 (2017). https://doi.org/10.1038/nature22084

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