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A hidden competitive advantage of disorder

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The cellular response to low oxygen levels is regulated by a process in which one protein is ousted from a binding site by another. It emerges that protein disorder allows the displacement to occur remarkably efficiently. See Letter p.447

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Figure 1: Efficient displacement of a protein from a binding site.

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References

  1. Berlow, R. B., Dyson, H. J. & Wright, P. E. Nature 543, 447–451 (2017).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  2. Arany, Z. et al. Proc. Natl Acad. Sci. USA 93, 12969–12973 (1996).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Yin, Z. et al. Proc. Natl Acad. Sci. USA 99, 10488–10493 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Swain, J. F. & Gierasch, L. M. Curr. Opin. Struct. Biol. 16, 102–108 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. Ferreon, A. C. M., Ferreon, J. C., Wright, P. E. & Deniz, A. A. Nature 498, 390–394 (2013).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  6. Garcia-Pino, A. et al. Nature Chem. Biol. 12, 490–496 (2016).

    Article  CAS  Google Scholar 

  7. Wright, P. E. & Dyson, H. J. Nature Rev. Mol. Cell Biol. 16, 18–29 (2015).

    Article  CAS  Google Scholar 

  8. Sharma, R., Raduly, Z., Miskei, M. & Fuxreiter, M. FEBS Lett. 589, 2533–2542 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Csizmok, V. et al. Nature Commun. 8, 13943 (2017).

    Article  ADS  CAS  Google Scholar 

  10. Mitrea, D. M. & Kriwacki, R. W. Cell Commun. Signal. 14, 1–20 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. P. Andrew Chong and Julie D. Forman-Kay are in the Program in Molecular Medicine, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.,

    P. Andrew Chong & Julie D. Forman-Kay

  2. J.D.F.-K. is also in the Biochemistry Department, University of Toronto.,

    Julie D. Forman-Kay

Authors
  1. P. Andrew Chong
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  2. Julie D. Forman-Kay
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Correspondence to Julie D. Forman-Kay.

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Chong, P., Forman-Kay, J. A hidden competitive advantage of disorder. Nature 543, 325–326 (2017). https://doi.org/10.1038/nature21893

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