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Stem cells

Valine starvation leads to a hungry niche

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The haematopoietic stem cells that rejuvenate blood depend on a dietary source of the amino acid valine — a finding that has been exploited to reduce the toxicity of bone-marrow transplantation in mice.

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Figure 1: Reducing toxicity in bone-marrow transplantation.

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Authors and Affiliations

  1. R. Grant Rowe and George Q. Daley are in the Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.,

    R. Grant Rowe & George Q. Daley

  2. G.Q.D. is also at the Howard Hughes Medical Institute, Boston.,

    George Q. Daley

Authors
  1. R. Grant Rowe
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  2. George Q. Daley
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Correspondence to George Q. Daley.

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Rowe, R., Daley, G. Valine starvation leads to a hungry niche. Nature 541, 166–167 (2017). https://doi.org/10.1038/nature21106

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