Plaque deposits often occur in curved arterial regions with turbulent blood flow. Endothelial cells have been found to respond to blood flow through a previously unidentified signalling pathway that affects plaque build-up. See Letter p.579
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References
Caro, C. G., Fitz-Gerald, J. M. & Schroter, R. C. Nature 223, 1159–1161 (1969).
Ross, R. N. N. Engl. J. Med. 340, 115–126 (1999).
Wang, L. et al. Nature 540, 579–582 (2016).
Chatzizisis, Y. S., Coskun, A. U., Jonas, M., Edelman, E. R., Feldman, C. L. & Stone, P. H. J. Am. Coll. Cardiol. 49, 2379–2393 (2007).
Dupont, S. et al. Nature 474, 179–183 (2011).
Piccolo, S., Dupont, S. & Cordenonsi, M. Physiol. Rev. 94, 1287–1312 (2014).
Schober, J. M. et al. Blood 99, 4457–4465 (2002).
Chaqour, B. & Goppelt-Struebe, M. FEBS J. 273, 3639–3649 (2006).
Zhou, J. et al. Proc. Natl Acad. Sci. USA 109, 7770–7775 (2012).
Zhang, S. H., Reddick, R. L., Burkey, B. & Maeda, N. J. Clin. Invest. 94, 937–945 (1994).
Nam, D. et al. Am. J. Physiol. Heart Circ. Physiol. 297, H1535–H1543 (2009).
Chen, J., Green, J., Yurdagul, A. Jr, Albert, P., McInnis, M. C. & Orr, A. W. Am. J. Pathol. 185, 2575–2589 (2015).
Maile, L. A. et al. Sci. Transl. Med. 2, 18ra11 (2010).
Hoshiga, M., Alpers, C. E., Smith, L. L., Giachelli, C. M. & Schwartz, S. M. Circ. Res. 77, 1129–1135 (1995).
Sorrentino, G. et al. Nature Cell Biol. 16, 357–366 (2014).
Wang, Z. et al. Proc. Natl Acad. Sci. USA 111, E89–E98 (2014).
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Mehta, V., Tzima, E. A turbulent path to plaque formation. Nature 540, 531–532 (2016). https://doi.org/10.1038/nature20489
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DOI: https://doi.org/10.1038/nature20489
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