Skip to main content
SpringerLink
Log in

Cancer

A gene-expression profile for leukaemia

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Can simple genetic risk profiles be identified for complex diseases? The development of a gene-expression profile for acute myeloid leukaemia suggests that they can, and that they may improve prognosis prediction. See Letter p.433

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A 17-gene score for assessing the risk of acute leukaemia.

Notes

  1. See all news & views

References

  1. Ng, S. W. K. et al. Nature 540, 433–437 (2016).

    Article  CAS  ADS  Google Scholar 

  2. Grimwade, D. et al. Blood 116, 354–365 (2010).

    Article  CAS  Google Scholar 

  3. Cornelissen, J. J. et al. Nature Rev. Clin. Oncol. 9, 579–590 (2012).

    Article  CAS  Google Scholar 

  4. Shivarov, V. & Bullinger, L. Exp. Hematol. 42, 651–660 (2014).

    Article  CAS  Google Scholar 

  5. Levine, J. H. et al. Cell 162, 184–197 (2015).

    Article  CAS  Google Scholar 

  6. Sarry, J.-E. et al. J. Clin. Invest. 121, 384–395 (2011).

    Article  CAS  Google Scholar 

  7. Verhaak, R. G. W. et al. Haematologica 94, 131–134 (2009).

    Article  Google Scholar 

  8. Gentles, A. J. et al. J. Am. Med. Assoc. 304, 2706–2715 (2010).

    Article  CAS  Google Scholar 

  9. Papaemmanuil, E. et al. N. Engl. J. Med. 374, 2209–2221 (2016).

    Article  CAS  Google Scholar 

  10. Ding, L. et al. Nature 481, 506–510 (2012).

    Article  CAS  ADS  Google Scholar 

  11. Jan, M. & Majeti, R. Oncogene 32, 135–140 (2013).

    Article  CAS  Google Scholar 

  12. Hokland P. et al. Semin. Hematol. 52, 184–192 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gerrit J. Schuurhuis is in the Department of Hematology, Free University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.,

    Gerrit J. Schuurhuis

Authors
  1. Gerrit J. Schuurhuis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gerrit J. Schuurhuis.

Related links

Related links

Related links in Nature Research

Cancer: Persistence of leukaemic ancestors

Cancer: Mutations close in on gene regulation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schuurhuis, G. A gene-expression profile for leukaemia. Nature 540, 346–348 (2016). https://doi.org/10.1038/nature20488

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature20488

  • Springer Nature Limited

This article is cited by

Search

Navigation