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Stem cells

Cause and consequence in aged-muscle decline

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Activation of aged muscle stem cells induces changes in DNA packaging that lead to expression of the gene Hoxa9. This reactivates embryonic signalling pathways, restricting the cells' ability to repair injured muscle. See Letter p.428

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Figure 1: A changing epigenetic landscape during ageing.

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Authors and Affiliations

  1. and the Department of Orthopaedic Surgery, Susan Eliazer and Andrew S. Brack are in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA.,

    Susan Eliazer & Andrew S. Brack

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  1. Susan Eliazer
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  2. Andrew S. Brack
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Correspondence to Andrew S. Brack.

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Developmental biology: Skeletal muscle comes of age

Ageing: Genetic rejuvenation of old muscle

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Eliazer, S., Brack, A. Cause and consequence in aged-muscle decline. Nature 540, 349–350 (2016). https://doi.org/10.1038/nature20485

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