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Catalytic spliceosome captured

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Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197

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Figure 1: Spliceosomal processing of RNA transcripts.
Figure 2: Model of the catalytically active spliceosome structure.

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Author information

Authors and Affiliations

  1. Brian Kosmyna and Charles C. Query are in the Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461-1975, USA.,

    Brian Kosmyna & Charles C. Query

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  1. Brian Kosmyna
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  2. Charles C. Query
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Correspondence to Brian Kosmyna or Charles C. Query.

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Kosmyna, B., Query, C. Catalytic spliceosome captured. Nature 537, 175–176 (2016). https://doi.org/10.1038/nature19422

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