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Mammalian development

Mechanics drives cell differentiation

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Several hypotheses have been formulated to explain how cells make the first lineage decision during mammalian embryonic development. An overarching mechanism now unifies these disparate models. See Letter p.344

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Figure 1: A fateful decision.

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Author information

Authors and Affiliations

  1. Berenika Plusa is in the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.,

    Berenika Plusa

  2. Anna-Katerina Hadjantonakis is in the Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.,

    Anna-Katerina Hadjantonakis

Authors
  1. Berenika Plusa
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  2. Anna-Katerina Hadjantonakis
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Corresponding authors

Correspondence to Berenika Plusa or Anna-Katerina Hadjantonakis.

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Plusa, B., Hadjantonakis, AK. Mechanics drives cell differentiation. Nature 536, 281–282 (2016). https://doi.org/10.1038/nature18920

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