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Diabetes

Still a geneticist's nightmare

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The largest DNA-sequencing study of type 2 diabetes conducted so far concludes that, contrary to expectation, low-frequency and rare genetic variants do not contribute significantly to disease risk. See Article p.41

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References

  1. Rewers, M. & Hamman, R. F. in Diabetes in America 2nd edn, Ch. 9, 179–220 (NIH, 1995).

    Google Scholar 

  2. Morris, A. P. et al. Nature Genet. 44, 981–990 (2012).

    Article  CAS  Google Scholar 

  3. Fuchsberger, C. et al. Nature 536, 41–47 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Steinthorsdottir, V. et al. Nature Genet. 46, 294–298 (2014).

    Article  CAS  Google Scholar 

  5. Cho, Y. S. et al. Nature Genet. 44, 67–72 (2012).

    Article  CAS  Google Scholar 

  6. Ma, R. C. W. et al. Diabetologia 56, 1291–1305 (2013).

    Article  CAS  Google Scholar 

  7. Neel, J. V. in The Genetics of Diabetes Mellitus (eds Creutzfeldt, W., Köbberling, J. & Neel, J. V.) 1–11 (Springer, 1976).

    Book  Google Scholar 

  8. Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobbs, H. H. N. Engl. J. Med. 354, 1264–1272 (2006).

    Article  CAS  Google Scholar 

  9. Bergman, R. N. et al. Diabetes 52, 2168–2174 (2003).

    Article  CAS  Google Scholar 

  10. Zeggini, E., Gloyn, A. L. & Hansen, T. Diabetologia 59, 938–941 (2016)

    Article  Google Scholar 

  11. Blangero, J. & Kent, J. W. Jr in Genetic and Molecular Aspects of Sport Performance (eds Bouchard, C. & Hoffman, E. P.) 33–45 (Wiley-Blackwell, 2011).

    Google Scholar 

  12. Lange, L. A. et al. Am. J. Hum. Genet. 94, 233–245 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Stephen S. Rich.

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Rich, S. Still a geneticist's nightmare. Nature 536, 37–38 (2016). https://doi.org/10.1038/nature18906

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