Sperm–egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins separately and in complex provides insight into the recognition process and the subsequent sperm–egg fusion. See Letters p.562 & p.566
Notes
References
Aydin, H., Sultana, A., Li, S., Thavalingam, A. & Lee, J. E. Nature 534, 562–565 (2016).
Ohto, U. et al. Nature 534, 566–569 (2016).
Krauchunas, A. R., Marcello, M. R. & Singson, A. Mol. Reprod. Dev. 83, 376–386 (2016).
Okabe, M. Development 140, 4471–4479 (2013).
Inoue, N., Ikawa, M., Isotani, A. & Okabe, M. Nature 434, 234–238 (2005).
Bianchi, E., Doe, B., Goulding, D. & Wright, G. J. Nature 508, 483–487 (2014).
Han, L. et al. Curr. Biol. 26, R100–R101 (2016).
Kato, K. et al. Nature Commun. http://dx.doi.org/10.1038/ncomms12198 (2016).
Chen, C. et al. Nature 500, 486–489 (2013).
Wibowo, A. S. et al. Proc. Natl Acad. Sci. USA 110, 15180–15188 (2013).
Yanagimachi, R., Yanagimachi, H. & Rogers, B. J. Biol. Reprod. 15, 471–476 (1976).
Inoue, N., Hagihara, Y., Wright, D., Suzuki, T. & Wada, I. Nature Commun. 6, 8858 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Melcher, K. When sperm meets egg. Nature 534, 484–485 (2016). https://doi.org/10.1038/nature18448
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature18448
- Springer Nature Limited