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Inflammation keeps old mice healthy

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Immune cells called regulatory T cells accumulate in fat during ageing. The anti-inflammatory activity of these cells worsens age-associated defects in metabolism, in contrast to its effect in obesity. See Letter p.137

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Figure 1: Regulatory T cells impair metabolic regulation in old fat.

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Correspondence to Ivan Maillard or Alan R. Saltiel.

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Maillard, I., Saltiel, A. Inflammation keeps old mice healthy. Nature 528, 44–46 (2015). https://doi.org/10.1038/nature15648

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