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Antibiotics

Homed to the hideout

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Some Staphylococcus aureus bacteria are thought to survive standard antibiotic treatment by 'hiding' in host cells. But an antibody–antibiotic conjugate has been developed that targets these bacteria in mouse models. See Article p.323

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Figure 1: Targeted intracellular antibiotic release.

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References

  1. Lehar, S. M. et al. Nature 527, 323–328 (2015).

    Article  CAS  ADS  Google Scholar 

  2. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  3. Lewis, K. Annu. Rev. Microbiol. 64, 357–372 (2010).

    Article  CAS  Google Scholar 

  4. Giang, I., Boland, E. L. & Poon, G. M. K. AAPS J. 16, 899–913 (2014).

    Article  CAS  Google Scholar 

  5. Joller, N. et al. Proc. Natl Acad. Sci. USA 107, 20441–20446 (2010).

    Article  CAS  ADS  Google Scholar 

  6. Yacoby, I. & Benhar, I. Infect. Disord. Drug Targets 7, 221–229 (2007).

    Article  CAS  Google Scholar 

  7. Conlon, B. P. et al. Nature 503, 365–370 (2013).

    Article  CAS  ADS  Google Scholar 

  8. Kaiser, P. et al. PLoS Biol. 12, e1001793 (2014).

    Article  Google Scholar 

  9. Porte, R. et al. Antimicrob. Agents Chemother. 59, 6064–6072 (2015).

    Article  CAS  Google Scholar 

  10. Iwase, T. et al. Nature 465, 346–349 (2010).

    Article  CAS  ADS  Google Scholar 

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Correspondence to Wolf-Dietrich Hardt.

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Hardt, WD. Homed to the hideout. Nature 527, 309–310 (2015). https://doi.org/10.1038/nature15647

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