Reactive oxygen species have been viewed as stress-inducing molecules that promote cancer initiation. But new evidence indicates that oxidative stress can be beneficial — inhibiting the spread of a cancer to other sites. See Article p.186
Notes
References
Gorrini, C., Harris, I. S. & Mak, T. W. Nature Rev. Drug Discov. 12, 931–947 (2013).
Sabharwal, S. S. & Schumacker, P. T. Nature Rev. Cancer 14, 709–721 (2014).
Piskounova, E. et al. Nature 527, 186–191 (2015).
Gao, P. et al. Cancer Cell 12, 230–238 (2007).
Klein, E. A. et al. J. Am. Med. Assoc. 306, 1549–1556 (2011).
Chandel, N. S. & Tuveson, D. A. N. Engl. J. Med. 371, 177–178 (2014).
Sayin, V. I. et al. Science Transl. Med. 6, 221ra15 (2014).
Schafer, Z. T. et al. Nature 461, 109–113 (2009).
DeNicola, G. M. et al. Nature 475, 106–109 (2011).
Harris, I. S. et al. Cancer Cell 27, 211–222 (2015).
Kandoth, C. et al. Nature 502, 333–339 (2013).
Cancer Genome Atlas Research Network Nature 489, 519–525 (2012).
Fan, J. et al. Nature 510, 298–302 (2014).
Le Gal, K. et al. Science Transl. Med. 7, 308re8 (2015).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Harris, I., Brugge, J. The enemy of my enemy is my friend. Nature 527, 170–171 (2015). https://doi.org/10.1038/nature15644
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature15644
- Springer Nature Limited
This article is cited by
-
Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma
Scientific Reports (2022)
-
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma
Laboratory Investigation (2021)
-
The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines
Investigational New Drugs (2019)
-
Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation
European Journal of Nutrition (2019)
-
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma
Laboratory Investigation (2018)