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Cancer

The enemy of my enemy is my friend

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Reactive oxygen species have been viewed as stress-inducing molecules that promote cancer initiation. But new evidence indicates that oxidative stress can be beneficial — inhibiting the spread of a cancer to other sites. See Article p.186

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Figure 1: Metabolic adaptation to oxidative stress promotes metastasis

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References

  1. Gorrini, C., Harris, I. S. & Mak, T. W. Nature Rev. Drug Discov. 12, 931–947 (2013).

    Article  CAS  Google Scholar 

  2. Sabharwal, S. S. & Schumacker, P. T. Nature Rev. Cancer 14, 709–721 (2014).

    Article  CAS  Google Scholar 

  3. Piskounova, E. et al. Nature 527, 186–191 (2015).

    Article  ADS  CAS  Google Scholar 

  4. Gao, P. et al. Cancer Cell 12, 230–238 (2007).

    Article  CAS  Google Scholar 

  5. Klein, E. A. et al. J. Am. Med. Assoc. 306, 1549–1556 (2011).

    Article  CAS  Google Scholar 

  6. Chandel, N. S. & Tuveson, D. A. N. Engl. J. Med. 371, 177–178 (2014).

    Article  CAS  Google Scholar 

  7. Sayin, V. I. et al. Science Transl. Med. 6, 221ra15 (2014).

    Article  Google Scholar 

  8. Schafer, Z. T. et al. Nature 461, 109–113 (2009).

    Article  ADS  CAS  Google Scholar 

  9. DeNicola, G. M. et al. Nature 475, 106–109 (2011).

    Article  CAS  Google Scholar 

  10. Harris, I. S. et al. Cancer Cell 27, 211–222 (2015).

    Article  CAS  Google Scholar 

  11. Kandoth, C. et al. Nature 502, 333–339 (2013).

    Article  ADS  CAS  Google Scholar 

  12. Cancer Genome Atlas Research Network Nature 489, 519–525 (2012).

  13. Fan, J. et al. Nature 510, 298–302 (2014).

    Article  ADS  CAS  Google Scholar 

  14. Le Gal, K. et al. Science Transl. Med. 7, 308re8 (2015).

    Article  Google Scholar 

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Correspondence to Isaac S. Harris or Joan S. Brugge.

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Harris, I., Brugge, J. The enemy of my enemy is my friend. Nature 527, 170–171 (2015). https://doi.org/10.1038/nature15644

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