Skip to main content
SpringerLink
Log in

Non-coding RNA

Antibiotic tricks a switch

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

A screen for compounds that block a bacterial biosynthetic pathway has uncovered an antibiotic lead that shuts off pathogen growth by targeting a molecular switch in a regulatory RNA structure. See Article p.672

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Metabolic-pathway blockade identifies an antibiotic.

Notes

  1. See all news & views

References

  1. Waksman, S. A. Mycologia 39, 565–569 (1947).

    Article  CAS  Google Scholar 

  2. Waksman, S. A. Science 118, 259–266 (1953).

    Article  CAS  ADS  Google Scholar 

  3. Howe, J. A. et al. Nature 526, 672–677 (2015).

    Article  CAS  ADS  Google Scholar 

  4. Infectious Diseases Society of America. Bad Bugs, No Drugs (IDSA, 2004).

  5. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  6. Matzner, D. & Mayer, G. J. Med. Chem. 58, 3275–3286 (2015).

    Article  CAS  Google Scholar 

  7. Dibrov, S. M. et al. J. Med. Chem. 57, 1694–1707 (2014).

    Article  CAS  Google Scholar 

  8. McCoy, L. S., Xie, Y. & Tor, Y. Wiley Interdisc. Rev. RNA 2, 209–232 (2011).

    Article  CAS  Google Scholar 

  9. Morris, K. V. & Mattick, J. S. Nature Rev. Genet. 15, 423–437 (2014).

    Article  CAS  Google Scholar 

  10. Taft, R. J., Pang, K. C., Mercer, T. R., Dinger, M. & Mattick, J. S. J. Pathol. 220, 126–139 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thomas Hermann is in the Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.,

    Thomas Hermann

Authors
  1. Thomas Hermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Hermann.

Related links

Related links

Related links in Nature Research

Antibiotics: An irresistible newcomer

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hermann, T. Antibiotic tricks a switch. Nature 526, 650–651 (2015). https://doi.org/10.1038/nature15635

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature15635

  • Springer Nature Limited

This article is cited by

Search

Navigation