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Parkinson's disease

Crystals of a toxic core

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An ultra-high-resolution structure of the core segment of assembled α-synuclein — the protein that aggregates in the brains of patients with Parkinson's disease — has been determined. A neurobiologist and a structural biologist discuss the implications of this advance. See Article p.486

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Figure 1: The core of α-synuclein fibrils.

a, Jose A. Rodriguez; b, Michael R. Sawaya

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References

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Author information

Authors and Affiliations

  1. Michel Goedert is at the MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.,

    Michel Goedert

  2. Yifan Cheng is at the Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA.,

    Yifan Cheng

Authors
  1. Michel Goedert
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  2. Yifan Cheng
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Corresponding authors

Correspondence to Michel Goedert or Yifan Cheng.

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Goedert, M., Cheng, Y. Crystals of a toxic core. Nature 525, 458–459 (2015). https://doi.org/10.1038/nature15630

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