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Network evolution hinges on history

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The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks. See Letter p.361

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Figure 1: Not all evolutionary paths are possible.

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Authors and Affiliations

  1. Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.,

    Aaron M. New & Ben Lehner

  2. B.L. is also at the Institució Catalana de Recerca i Estudis Avançats, Barcelona.,

    Ben Lehner

Authors
  1. Aaron M. New
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  2. Ben Lehner
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Correspondence to Ben Lehner.

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New, A., Lehner, B. Network evolution hinges on history. Nature 523, 297–298 (2015). https://doi.org/10.1038/nature14537

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