The discovery of peptides encoded by what were thought to be non-coding – or 'junk' – regions of precursors to microRNA sequences reveals a new layer of gene regulation. These sequences may not be junk, after all. See Letter p.90
Notes
References
Ameres, S. L. & Zamore, P. D. Nature Rev. Mol. Cell Biol. 14, 475–488 (2013).
Lauressergues, D. et al. Nature 520, 90–93 (2015).
Birney, E. et al. Nature 489, 57–74 (2012).
Kellis, M. et al. Proc. Natl Acad. Sci. USA 111, 6131–6138 (2014).
Carthew, R. W. & Sontheimer, E. J. Cell 136, 642–655 (2009).
Fang, Y. & Spector, D. L. Curr. Biol. 17, 818–823 (2007).
Zhang, L. et al. PLoS Genet. 5, e1000716 (2009).
Cuperus, J. T., Fahlgren, N. & Carrington, J. C. Plant Cell 23, 431–442 (2011).
Andrews, S. J. & Rothnagel, J. A. Nature Rev. Genet. 15, 193–204 (2014).
Laing, W. A. et al. Plant Cell http://dx.doi.org/10.1105/tpc.114.133777 (2015).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Waterhouse, P., Hellens, R. Coding in non-coding RNAs. Nature 520, 41–42 (2015). https://doi.org/10.1038/nature14378
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature14378
- Springer Nature Limited
This article is cited by
-
Primary transcript of miR858 encodes regulatory peptide and controls flavonoid biosynthesis and development in Arabidopsis
Nature Plants (2020)
-
Transcriptome and miRNA analyses of the response to Corynespora cassiicola in cucumber
Scientific Reports (2018)
-
Genome-wide bisulphite-sequencing reveals organ-specific methylation patterns in chickpea
Scientific Reports (2018)
-
MiR-285 targets P450 (CYP6N23) to regulate pyrethroid resistance in Culex pipiens pallens
Parasitology Research (2016)