References
Cruchaga, C. et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 505, 550–554 (2014)
van der Lee, S. J. et al. PLD3 variants in population studies. Nature 520, http://dx.doi.org/10.1038/nature14038 (2015).
Heilmann, S. et al. PLD3 in non-familial Alzheimer's disease. Nature 520, http://dx.doi.org/10.1038/nature14039 (2015).
Lambert, J.-C. et al. PLD3 and sporadic Alzheimer's disease risk. Nature 520, http://dx.doi.org/10.1038/nature14036 (2015).
Moore, C. B. et al. Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data. PLoS Genet. 9, e1003959 (2013).
Mathieson, I. & McVean, G. Differential confounding of rare and common variants in spatially structured populations. Nature Genet. 44, 243–246 (2012).
Schulte, E. C. et al. Excess of rare coding variants in PLD3 in late- but not earlyonset Alzheimer's disease. Human Genome Var. 2, 14028 (2015).
van der Lee, S. J. et al. PLD3 associates to proline a proposed biomarker in Mapstone et al. Alzheimers Dement. 10, P887–P888 (2014).
Mapstone, M. et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nature Med. 20, 415–418 (2014).
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Cruchaga, C., Goate, A. Cruchaga & Goate reply. Nature 520, E5–E6 (2015). https://doi.org/10.1038/nature14037
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DOI: https://doi.org/10.1038/nature14037
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