The crystal structure of the COP9 signalosome, a large protein complex that regulates intracellular protein degradation, reveals how the complex achieves exquisite specificity for its substrates. See Article p.161
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References
Wei, N., Chamovitz, D. A. & Deng, X.-W. Cell 78, 117–124 (1994).
Lingaraju, G. M. et al. Nature 512, 161–165 (2014).
Lyapina, S. et al. Science 292, 1382–1385 (2001).
Cope, G. A. et al. Science 298, 608–611 (2002).
Fischer, E. S. et al. Cell 147, 1024–1039 (2011).
Emberley, E. D., Mosadeghi, R. & Deshaies, R. J. J. Biol. Chem. 287, 29679–29689 (2012).
Enchev, R. I. et al. Cell Rep. 2, 616–627 (2012).
Ambroggio, X. I., Rees, D. C. & Deshaies, R. J. PLoS Biol. 2, e2 (2004).
Suh, G. S. B. et al. Neuron 33, 35–46 (2002).
Sato, Y. et al. Nature 455, 358–362 (2008).
Pathare, G. R. et al. Proc. Natl Acad. Sci. USA 111, 2984–2989 (2014).
Worden, E. J., Padovani, C. & Martin, A. Nature Struct. Mol. Biol. 21, 220–227 (2014).
Śledź, P. et al. Proc. Natl Acad. Sci. USA 110, 7264–7269 (2013).
Matyskiela, M. E., Lander, G. C. & Martin, A. Nature Struct. Mol. Biol. 20, 781–788 (2013).
Echalier, A. et al. Proc. Natl Acad. Sci. USA 110, 1273–1278 (2013).
Adler, A. S. et al. Cancer Res. 68, 506–515 (2008).
Lee, Y.-H. et al. Oncogene 30, 4175–4184 (2011).
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Deshaies, R. Corralling a protein-degradation regulator. Nature 512, 145–146 (2014). https://doi.org/10.1038/nature13644
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DOI: https://doi.org/10.1038/nature13644
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