The transcription factor Myc has been posited to cause a cell-wide increase in gene expression. But two studies show that Myc, when modulated by other transcription factors, can amplify select targets. See Letters p.483 and p.488
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Dang, C. Fine-tuned amplification in cells. Nature 511, 417–418 (2014). https://doi.org/10.1038/nature13518
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DOI: https://doi.org/10.1038/nature13518
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