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Alzheimer's disease

A protective factor for the ageing brain

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What guards the aged brain against neurodegeneration? A study finds that the REST protein has a central role in protecting ageing neurons from death and in maintaining cognitive capacity in the elderly. See Article p.448

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Figure 1: REST activation distinguishes healthy aged brains from the brains of those with Alzheimer's disease.

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Authors and Affiliations

  1. Department of Brain and Cognitive Sciences, Li-Huei Tsai and Ram Madabhushi are at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.,

    Li-Huei Tsai & Ram Madabhushi

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  1. Li-Huei Tsai
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  2. Ram Madabhushi
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Correspondence to Li-Huei Tsai.

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Tsai, LH., Madabhushi, R. A protective factor for the ageing brain. Nature 507, 439–440 (2014). https://doi.org/10.1038/nature13214

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