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Lipopolysaccharide sensing on the inside

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Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.

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Figure 1: Inflammasome activation by caspase-11.

Notes

  1. *This News & Views article was published online on 4 September 2013.

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Authors and Affiliations

  1. Vijay A. K. Rathinam and Katherine A. Fitzgerald are in the Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.,

    Vijay A. K. Rathinam & Katherine A. Fitzgerald

Authors
  1. Vijay A. K. Rathinam
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  2. Katherine A. Fitzgerald
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Correspondence to Katherine A. Fitzgerald.

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Rathinam, V., Fitzgerald, K. Lipopolysaccharide sensing on the inside. Nature 501, 173–175 (2013). https://doi.org/10.1038/nature12556

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