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Helenius et al. reply

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Abstract

Replying to: Frank, C. G., Sanyal, S., Rush, J. S., Waechter C. J. & Menon A. K. Nature 454, 10.1038/nature07165 (2008)

The controlled translocation of polar phospholipid head groups between the two leaflets of biological membranes is thought to be meditated by proteins called flippases. Several candidate polyisoprene phosphate–oligosaccharide flippases have been described1,2,3, including Rft1 for Dol-PP-GlcNAc2Man5 by us4 and now questioned by Frank et al.5.

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Author notes

  1. Jonne Helenius & Davis T. W. Ng

    Present address: †Present addresses: Biotechnology Centre, University of Technology Dresden, D-01307 Dresden, Germany (J.H.); Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604 (D.T.W.N.).,

Authors and Affiliations

  1. Institute of Microbiology, Swiss Federal Institute of Technology, Zürich, CH-8092, Zürich, Switzerland

    Jonne Helenius & Markus Aebi

  2. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA

    Davis T. W. Ng

  3. Department of Microbiology and Immunology, University of Western Ontario, London, N6A 5C1, Ontario, Canada

    Cristina L. Marolda & Miguel A. Valvano

  4. Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, 94143-0448, California, USA

    Peter Walter

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  1. Jonne Helenius
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Helenius, J., Ng, D., Marolda, C. et al. Helenius et al. reply. Nature 454, E4–E5 (2008). https://doi.org/10.1038/nature07164

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