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Neurophysiology

Hodgkin and Huxley model — still standing? (Reply)

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Abstract

McCormick et al.1 question whether the rapid onset and highly variable thresholds of action potentials2 are genuine features of cortical action-potential generators — that is, whether they reflect the voltage-dependence of the underlying sodium currents. Instead, they consider these features to be epiphenomena, reflecting lateral currents from a remote initiation site, and, contrary to direct evidence3, they assume that sodium currents show canonical kinetics.

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References

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Authors and Affiliations

  1. Department of Physics and Bernstein Center for Computational Neuroscience, Max Planck Institute for Dynamics and Self-Organization, University of Göttingen, Göttingen, 37073, Germany

    Björn Naundorf & Fred Wolf

  2. Department of Neurophysiology, Ruhr-University Bochum, Bochum, 44780, Germany

    Maxim Volgushev

  3. Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Science, Moscow, 117485, Russia

    Maxim Volgushev

Authors
  1. Björn Naundorf
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  2. Fred Wolf
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  3. Maxim Volgushev
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Correspondence to Fred Wolf.

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Naundorf, B., Wolf, F. & Volgushev, M. Hodgkin and Huxley model — still standing? (Reply). Nature 445, E2–E3 (2007). https://doi.org/10.1038/nature05534

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