Skip to main content
SpringerLink
Log in

A brief proposal for improving clinical trials

Recent advances in diagnostics may significantly inspire and streamline clinical trials

  • News and Commentary
  • Published:
Molecular Psychiatry Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Niculescu AB, Levey D, Le-Niculescu H, Niculescu E, Kurian SM, Salomon D . Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Mol Psychiatry 2015; 20: 286–288.

    Article  CAS  Google Scholar 

  2. Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry 2013; 18: 1249–1264.

    Article  CAS  Google Scholar 

  3. Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N et al. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol Psychiatry 2015; 20: 1266–1285.

    Article  CAS  Google Scholar 

  4. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ et al. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 653–662.

    Article  Google Scholar 

  5. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Miriami E et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012; 148: 1293–1307.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by an NIH Directors’ New Innovator Award (1DP2OD007363) and a VA Merit Award (2I01CX000139) to ABN. I would like to thank members of the Niculescu group for their excellent work over the years, and helpful discussions and comments, particularly, Helen Le-Niculescu, Daniel Levey and Peter Phalen.

Author information

Authors and Affiliations

  1. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

    A B Niculescu

  2. Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA

    A B Niculescu

  3. Indianapolis Veterans Affairs Medical Center, Indianapolis, IN, USA

    A B Niculescu

Authors
  1. A B Niculescu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A B Niculescu.

Ethics declarations

Competing interests

The author declares no conflict of interest related to this work. ABN is listed as inventor on a patent application being filed by Indiana University.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Niculescu, A. A brief proposal for improving clinical trials. Mol Psychiatry 21, 736–737 (2016). https://doi.org/10.1038/mp.2016.42

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/mp.2016.42

  • Springer Nature Limited

This article is cited by

Search

Navigation