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Does ruxolitinib improve survival of persons with MPN-associated myelofibrosis? Should it?

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References

  1. Pardanani A, Vannucchi AM, Passamonti F, Cervantes F, Barbui T, Tefferi A . JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia 2011; 25: 218–225.

    Article  CAS  Google Scholar 

  2. Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med 2010; 363: 1117–1127.

    Article  CAS  Google Scholar 

  3. Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012; 366: 799–807.

    Article  CAS  Google Scholar 

  4. Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012; 366: 787–798.

    Article  CAS  Google Scholar 

  5. Mesa R, Gale RP . Hypothesis: How do JAK2-inhibitors work in myelofibrosis. Leuk Res 2009; 33: 1156–1157.

    Article  CAS  Google Scholar 

  6. Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF . Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica 2013; 98: 1865–1871.

    Article  CAS  Google Scholar 

  7. Cervantes F, Vannucchi AM, Kiladjian JJ, Al-Ali HK, Sirulnik A, Stalbovskaya V et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood 2013; 122: 4047–4053.

    Article  CAS  Google Scholar 

  8. Verstovsek S, Kantarjian HM, Estrov Z, Cortes JE, Thomas DA, Kadia T et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls. Blood 2012; 120: 1202–1209.

    Article  CAS  Google Scholar 

  9. Passamonti F, Cervantes F, Vannucchi AM, Morra E, Rumi E, Pereira A et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010; 115: 1703–1708.

    Article  CAS  Google Scholar 

  10. Tefferi A, Litzow MR, Pardanani A . Long-term outcome of treatment with ruxolitinib in Myelofibrosis. N Engl J Med 2011; 365: 1455–1457.

    Article  CAS  Google Scholar 

  11. Little RJ, D'Agostino R, Cohen ML, Dickersin K, Emerson SS, Farrar JT et al. The prevention and treatment of missing data in clinical trials. N Engl J Med 2012; 367: 1355–1360.

    Article  CAS  Google Scholar 

  12. Hernán MA, Hernández-Díaz S, Robins JM . Randomized trials analyzed as observational studies. Ann Intern Med 2013; 159: 560–562.

    Google Scholar 

  13. Passamonti F, Maffioli M, Cervantes F, Vannucchi AM, Morra E, Barbui T et al. Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts. Blood 2014; 123: 1833–1835.

    Article  CAS  Google Scholar 

  14. Xu Z, Gale RP, Zhang Y, Qin T, Chen H, Zhang P et al. Unique features of primary myelofibrosis in Chinese. Blood 2012; 119: 2469–2473.

    Article  CAS  Google Scholar 

  15. Liberati A . Need to realign patient-oriented and commercial and academic research. Lancet 2011; 378: 1777–1778.

    Article  Google Scholar 

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Acknowledgements

GB was supported by a grant from Associazione Italiana per la Ricerca sul Cancro (AIRC, Milano) 'Special Program Molecular Clinical Oncology 5 × 1000' to AGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative).

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Correspondence to G Barosi.

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Competing interests

RPG is a part-time employee of Celgene Corp. GB participated in advisory boards from Novartis and Sanofi. M-JZ declares no conflict of interest.

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Barosi, G., Zhang, MJ. & Gale, R. Does ruxolitinib improve survival of persons with MPN-associated myelofibrosis? Should it?. Leukemia 28, 2267–2270 (2014). https://doi.org/10.1038/leu.2014.220

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