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Deoxycytidine kinase is downregulated in Ara-C-resistant acute myeloid leukemia murine cell lines

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References

  1. Yin B, Kogan SC, Dickins RA, Lowe SW, Largaespada DA . Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Exp Hematol 2006; 34: 631–641.

    Article  CAS  PubMed  Google Scholar 

  2. Shi JY, Shi ZZ, Zhang SJ, Zhu YM, Gu BW, Li G et al. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. Pharmacogenetics 2004; 14: 759–768.

    Article  CAS  PubMed  Google Scholar 

  3. Veuger MJ, Honders MW, Landegent JE, Willemze R, Barge RM . High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia. Blood 2000; 96: 1517–1524.

    CAS  PubMed  Google Scholar 

  4. Song JH, Kim SH, Kweon SH, Lee TH, Kim HJ, Kim HJ et al. Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells. Int J Oncol 2009; 34: 1165–1171.

    CAS  PubMed  Google Scholar 

  5. Jiang Y, Prunier C, Howe PH . The inhibitory effects of disabled-2 (Dab2) on Wnt signaling are mediated through Axin. Oncogene 2008; 27: 1865–1875.

    Article  CAS  PubMed  Google Scholar 

  6. Akyerli CB, Beksac M, Holko M, Frevel M, Dalva K, Ozbek U et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk Res 2005; 29: 283–286.

    Article  CAS  PubMed  Google Scholar 

  7. Kongkham PN, Northcott PA, Ra YS, Nakahara Y, Mainprize TG, Croul SE et al. An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma. Cancer Res 2008; 68: 9945–9953.

    Article  CAS  PubMed  Google Scholar 

  8. Chuthapisith S, Bean BE, Cowley G, Eremin JM, Samphao S, Layfield R et al. Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. Eur J Cancer 2009; 45: 1274–1281.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We acknowledge support from the Leukemia and Lymphoma Society of America (LLS 7019-04, Specialized Center of Research) and the Leukemia Research Fund (University of Minnesota). We especially thank Teng Zhang for his assistance with the drug assay and Natashay J Bailey for her work on the growth assay.

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Correspondence to S K Rathe.

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Rathe, S., Largaespada, D. Deoxycytidine kinase is downregulated in Ara-C-resistant acute myeloid leukemia murine cell lines. Leukemia 24, 1513–1515 (2010). https://doi.org/10.1038/leu.2010.88

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