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The first case of acute lymphoblastic leukemia with the e19a2 BCR–ABL1 transcript: imatinib therapy followed by unrelated donor transplantation induces a durable molecular response

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References

  1. Saglio G, Guerrasio A, Rosso C, Zaccaria A, Tassinari A, Serra A et al. New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1990; 76: 1819–1824.

    CAS  Google Scholar 

  2. Pane F, Frigeri F, Sindona M, Luciano L, Ferrara F, Cimino R et al. Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction). Blood 1996; 88: 2410–2414.

    CAS  Google Scholar 

  3. Pane F, Intrieri M, Quintarelli C, Izzo B, Muccioli GC, Salvatore F . BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations. Oncogene 2002; 21: 8652–8667.

    Article  CAS  Google Scholar 

  4. Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O . Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. Cancer Genet Cytogenet 2010; 199: 56–61.

    Article  CAS  Google Scholar 

  5. Lee S, Kim YJ, Min CK, Kim HJ, Eom KS, Kim DW et al. The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2005; 105: 3449–3457.

    Article  CAS  Google Scholar 

  6. Lee JJ, Kim HJ, Kim YJ, Lee S, Hwang JY, Kim YL et al. Imatinib induces a cytogenetic response in blast crisis or interferon failure chronic myeloid leukemia patients with e19a2 BCR-ABL transcripts. Leukemia 2004; 18: 1539–1540.

    Article  CAS  Google Scholar 

  7. Bennour A, Beaufils N, Sennana H, Meddeb B, Saad A, Gabert J . E355G mutation appearing in a patient with e19a2 chronic myeloid leukaemia resistant to imatinib. J Clin Pathol 2010; 63: 737–740.

    Article  CAS  Google Scholar 

  8. Popovici C, Charbonnier A, Gisserot O, Aguilon P, Rémy V, Olschwang S et al. Y253H mutation appearing in a micro-BCR-ABL (e19a2) CML. Leuk Res 2008; 32: 361–362.

    Article  CAS  Google Scholar 

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Acknowledgements

We wish to acknowledge the financial support of the Industry-Academic Cooperation Research Foundation made in the program year of 2009.

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Authors and Affiliations

  1. Department of Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea

    E K Jeon

  2. Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

    J Lim & M Kim

  3. Department of Hematology, Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea

    S-A Yahng, S-E Lee, B-S Cho, Y-J Kim, H-J Kim, C-K Min, S-G Cho, D-W Kim, J-W Lee, W-S Min, C-W Park & S Lee

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  1. E K Jeon
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  2. J Lim
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  3. M Kim
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Correspondence to S Lee.

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Jeon, E., Lim, J., Kim, M. et al. The first case of acute lymphoblastic leukemia with the e19a2 BCR–ABL1 transcript: imatinib therapy followed by unrelated donor transplantation induces a durable molecular response. Leukemia 25, 366–367 (2011). https://doi.org/10.1038/leu.2010.265

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