Skip to main content
SpringerLink
Log in

Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Tallman MS, Neuberg D, Bennett JM, Francois CJ, Paietta E, Wiernik PH et al. Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood 2000; 96: 2405–2411.

    CAS  PubMed  Google Scholar 

  2. Barnard DR, Alonzo TA, Gerbing RB, Lange B, Woods WG . Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: Report from the Children's Oncology Group. Pediatr Blood Cancer 2007; 49: 17–22.

    Article  Google Scholar 

  3. Gamis AS . Acute myeloid leukemia and Down syndrome evolution of modern therapy—state of the art review. Pediatr Blood Cancer 2005; 44: 13–20.

    Article  Google Scholar 

  4. Wickrema A, Crispino JD . Erythroid and megakaryocytic transformation. Oncogene 2007; 26: 6803–6815.

    Article  CAS  Google Scholar 

  5. Malinge S, Ragu C, Della-Valle V, Pisani D, Constantinescu SN, Perez C et al. Activating mutations in human acute megakaryoblastic leukemia. Blood 2008; 112: 4220–4226.

    Article  CAS  Google Scholar 

  6. Hussein K, Bock O, Theophile K, Schulz-Bischof K, Porwit A, Schlue J et al. MPLW515L mutation in acute megakaryoblastic leukaemia. Leukemia 2009; 23: 852–855.

    Article  CAS  Google Scholar 

  7. Grabher C, von Boehmer H, Look AT . Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006; 6: 347–359.

    Article  CAS  Google Scholar 

  8. Levine RL, Pardanani A, Tefferi A, Gilliland DG . Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat Rev Cancer 2007; 7: 673–683.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank the Eastern Cooperative Group (ECOG) and Children's Oncology Group (COG) for contributing specimens to this study. DS-AMKL and TMD samples from study COG A2971 were supported by the National Cancer Institute Grant nos U10 CA98543 and U10 CA98413. This work was also supported in part by the National Cancer Institute Grant no CA101774 to JDC.

Author information

Author notes

  1. R Bhat and S Malinge: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Hematology-Oncology, Children's Memorial Hospital, Chicago, IL, USA

    R Bhat

  2. Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    R Bhat, S Malinge, M S Tallman & J D Crispino

  3. Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospital and Clinics, Kansas City, MO, USA

    A S Gamis

  4. Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA, USA

    A D Sorrell

  5. Peyton Manning Children's Hospital at St. Vincent, Indianapolis, IN, USA

    J M Hilden

  6. Division of Laboratory Genetics, Mayo Clinic, Rochester, MN, USA

    R P Ketterling

  7. Department of Oncology, Montefiore Medical Center, Bronx, NY, USA

    E Paietta

Authors
  1. R Bhat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Malinge
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A S Gamis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A D Sorrell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J M Hilden
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R P Ketterling
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E Paietta
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M S Tallman
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J D Crispino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J D Crispino.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhat, R., Malinge, S., Gamis, A. et al. Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia. Leukemia 23, 2159–2160 (2009). https://doi.org/10.1038/leu.2009.159

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2009.159

  • Springer Nature Limited

This article is cited by

Search

Navigation