Skip to main content

Advertisement

Log in

Perinatal/Neonatal Case Presentation

Toxic epidermal necrolysis in a neonate receiving fluconazole

  • Perinatal/Neonatal Case Presentation
  • Published:
Journal of Perinatology Submit manuscript

Abstract

Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous condition, which may occur as an adverse reaction to a number of medications. The anitifungal agent, fluconazole, has been associated with TEN in limited reports, mainly in adults with HIV infection. We describe the case of a neonate with liver disease who developed TEN, presumably induced by fluconazole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

Similar content being viewed by others

References

  1. Roujeau JC, Stern R . Medical progress: severe cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272–1285.

    Article  CAS  Google Scholar 

  2. Ofoma UR, Chapnick EK . Fluconazole induced toxic-epidermal necrolysis: a case report. Cases J 2009; 2: 9071.

    Article  Google Scholar 

  3. George J, Sharma A, Dixit R, Chabra N, Sharma S . Toxic epidermal necrolysis caused by fluconazole in a patient with human immunodefiency virus infection. J Pharmacol Pharmacother 2012; 3: 276–278.

    Article  CAS  Google Scholar 

  4. Paquet O, Pierard GE, Quatresooz P . Novel treatments for drug-induced toxic epidermal necrolysis (Lyell’s Syndrome). Int Arch Allergy Immunol 2005; 136: 205–216.

    Article  CAS  Google Scholar 

  5. Azon-Masoliver A, Vilaplana J . Fluconazole-induced toxic epidermal necrolysis in a patient with human immunodeficiency syndrome. Dermatology 1993; 187: 268–269.

    Article  CAS  Google Scholar 

  6. Gussenhoven MJ, Haak A, Peereboom-Wynia JD, Van’t Wout JW . Stevens-Johnson syndrome after fluconazole. Lancet 1991; 338: 120.

    Article  CAS  Google Scholar 

  7. Craythorne E, Creamer D . Stevens–Johnson syndrome due to prophylactic fluconazole in two patients with liver failure. Clin Exp Dermatol. 2009; 34 (7): e389–e390.

    Article  CAS  Google Scholar 

  8. Pasmatzi E, Monastirli A, Georgiou S, Sqouros G, Tsambaos D . Short-term and low-dose oral fluconazole treatment can cause Steven-Johnson-Syndrome in HIV-negative patients. J Drug Dermatol 2011; 10: 1360.

    Google Scholar 

  9. Levi N, Bastuji-Garin S, Mockenaupt M, Roujeau JC, Flahault A, Kelly JP et al. Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis. Pediatrics 2009; 123 (2): e297–e304.

    Article  Google Scholar 

  10. Egunsola O, Adefurin A, Fakis A, Jacqz-Aigran E, Choonara I, Sammons H et al. Safety of fluconazole in paediatrics: a systematic review. Eur J Clin Pharmacol 2013; 69: 1211–1212.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S Islam.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Islam, S., Singer, M. & Kulhanjian, J. Toxic epidermal necrolysis in a neonate receiving fluconazole. J Perinatol 34, 792–794 (2014). https://doi.org/10.1038/jp.2014.92

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2014.92

  • Springer Nature America, Inc.

This article is cited by

Navigation