Abstract
We report a case of acute aortic dissection (Stanford type B) that occurred in pregnant woman at 34-week gestation. She had no systemic characteristics of Marfan syndrome, however she exhibited a mutation of FBN1, Arg 545 Cys, which has been found to correlate with ectopia lentis but not with aortic dissection.
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Loeys B, Nuytinck L, Delvaux I, De Bie S, De Paepe A . Genotype and phenotype analysis of 171 patients referred for molecular study of the fibrillin-1 gene FBN1 because of suspected Marfan syndrome. Arch Intern Med 2001; 161: 2447–2454.
Hayward C, Porteous ME, Brock DJ . Mutation screening of all 65 exons of the fibrillin-1 gene in 60 patients with Marfan syndrome: report of 12 novel mutations. Hum Mutat 1997; 10 (4): 280–289.
Comeglio P, Evans AL, Brice G, Cooling RJ, Child AH . Identification of FBN1 gene mutations in patients with ectopia lentis and marfanoid habitus. Br J Ophthalmol 2002; 86 (12): 1359–1362.
Lönnqvist L, Child A, Kainulainen K, Davidson R, Puhakka L, Peltonen L . A novel mutation of the fibrillin gene causing ectopia lentis. Genomics 1994; 19 (3): 573–576.
Brautbar A, LeMaire SA, Franco LM, Coselli JS, Milewicz DM, Belmont JW . FBN 1 mutations in patients with descending aortic dissections. Am J Med Genet 2010; 152A: 413–416.
Adès LC, Holman KJ, Brett MS, Edwards MJ, Bennetts B . Ectopia lentis phenotype and FBN1 gene. Am J Med Genet 2004; 126A: 284–289.
Houston L, Tuuli M, Macones G . Marfan syndrome and aortic dissection in pregnancy. Obstet Gynecol 2010; 115 (2 Pt 2): 460–462.
Immer FF, Bansi AG, Immer-Bansi AS, McDougall J, Zehr KJ, Schaff HV et al. Aortic dissection in pregnancy: analysis of risk factors and outcome. Ann Thorac Surg 2003; 76: 309–314.
Lipscomb KJ, Smith JC, Bernard C, Donnai P, Harris R . Outcome of pregnancy in women with Marfan’s syndrome. Br J Obstet Gynaecol 1997; 104: 201–206.
Rosenberger LH, Adams JD, Kern JA, Tracci MC, Angle JF, Cherry KJ . Complicated postpartum type B aortic dissection and endovascular repair. Obstet Gynecol 2012; 119: 480–483.
Braverman AC . Acute aortic dissection, clinical update. Circulation 2010; 122: 184–188.
Pacini L, Digne F, Boumendil A, Muti C, Detaint D, Boileau C et al. Maternal complication of pregnancy in Marfan syndrome. Int J Cardiol 2009; 136: 156–161.
Goland S, Elkayam Y . Cardiovascular problems in pregnant women with Marfan syndrome. Circulation 2009; 119: 619–623.
Judge DP, Diez HC . Marfan’s syndrome. Lancet 2005; 336: 1965–1976.
Ammash NM, Sundt TM, Connolly HM . Marfan syndrome-diagnosis and management. Curr Probl Cardiol 2008; 31: 7–39.
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Katsuragi, S., Neki, R., Yoshimatsu, J. et al. Acute aortic dissection (Stanford type B) during pregnancy. J Perinatol 33, 484–485 (2013). https://doi.org/10.1038/jp.2012.123
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DOI: https://doi.org/10.1038/jp.2012.123
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