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Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese men

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Abstract

Background:

Previous patterns of energy intake influence gastrointestinal function and appetite, probably reflecting changes in small-intestinal nutrient-mediated feedback. Obese individuals consume more fat and may be less sensitive to its gastrointestinal and appetite-suppressant effects than lean individuals.

Objective:

To evaluate the hypothesis that, in obese individuals, the effects of duodenal fat on gastrointestinal motor and hormone function, and appetite would be enhanced by a short period on a very-low-calorie diet (VLCD).

Methods:

Eight obese men (body mass index 34±0.6 kg m−2) were studied on two occasions, before (V1), and immediately after (V2), a 4-day VLCD. On both occasions, antropyloroduodenal motility, plasma cholecystokinin (CCK), peptide-YY (PYY) and ghrelin concentrations, and appetite perceptions were measured during a 120-min intraduodenal fat infusion (2.86 kcal min−1). Immediately afterwards, energy intake was quantified.

Results:

During V2, basal pyloric pressure and the number and amplitude of isolated pyloric pressure waves (PWs) were greater, whereas the number of antral and duodenal PWs was less, compared with V1 (all P<0.05). Moreover, during V2, baseline ghrelin concentration was higher; the stimulation of PYY and suppression of ghrelin by lipid were greater, with no difference in CCK concentration; and hunger and energy intake (kJ; V1: 4378±691, V2: 3634±700) were less (all P<0.05), compared with V1.

Conclusions:

In obese males, the effects of small-intestinal lipid on gastrointestinal motility and some hormone responses and appetite are enhanced after a 4-day VLCD.

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Acknowledgements

IM Brennan and RV Seimon were supported by Dawes Postgraduate Scholarships provided by the Royal Adelaide Hospital and the University of Adelaide, and C Feinle-Bisset by a Clinical Career Development Award (grant 299074, 2004–2009) from the National Health and Medical Research Council of Australia (NHMRC). The research was funded by an NHMRC project grant to C Feinle-Bisset (Grant 565312, 2009–2011).

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Authors and Affiliations

  1. University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

    I M Brennan, R V Seimon, N D Luscombe-Marsh, M Horowitz & C Feinle-Bisset

  2. NHMRC Centre of Clinical Research Excellence in Nutritional Physiology, Interventions and Outcomes, University of Adelaide, Adelaide, South Australia, Australia

    I M Brennan, R V Seimon, N D Luscombe-Marsh, M Horowitz & C Feinle-Bisset

  3. Medizinische Klinik, Klinikum Innenstadt, University of Munich, Munich, Germany

    B Otto

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  1. I M Brennan
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Correspondence to C Feinle-Bisset.

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Author contributions

IM Brennan was involved in study concept and design, data acquisition, data analysis and interpretation, statistical analysis and manuscript writing, RV Seimon in data acquisition and manuscript writing, ND Luscombe-Marsh in study concept and design and manuscript writing, B Otto performed the hormone assays and was involved in data analysis, M Horowitz was involved in study concept and design, data interpretation and manuscript writing, and C Feinle-Bisset was involved in study concept and design, data analysis and interpretation, statistical analysis and manuscript writing, obtained the funding and had overall responsibility for the study.

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Brennan, I., Seimon, R., Luscombe-Marsh, N. et al. Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese men. Int J Obes 35, 448–456 (2011). https://doi.org/10.1038/ijo.2010.153

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