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The AMPK signaling cascade in metabolic regulation: view from the chair

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References

  1. Kahn BB, Alquier T, Carling D, Hardie DG . AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1: 15–25.

    Article  CAS  Google Scholar 

  2. Xue B, Kahn BB . AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 2006; 574: 73–83.

    Article  CAS  Google Scholar 

  3. Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 2005; 280: 25196–25201.

    Article  CAS  Google Scholar 

  4. Birk JB, Wojtaszewski JF . Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol 2006; 577: 1021–1032.

    Article  CAS  Google Scholar 

  5. Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 2005; 24: 1810–1820.

    Article  CAS  Google Scholar 

  6. Thomson DM, Porter BB, Tall JH, Kim HJ, Barrow JR, Winder WW . Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. Am J Physiol Endocrinol Metab 2007; 292: E196–E202.

    Article  CAS  Google Scholar 

  7. Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y et al. Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J 2005; 19: 1146–1148.

    Article  Google Scholar 

  8. Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ . AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J Biol Chem 2006; 281: 31478–31485.

    Article  CAS  Google Scholar 

  9. Sano H, Kane S, Sano E, Mîinea CP, Asara JM, Lane WS et al. Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem 2003; 278: 14599–14602.

    Article  CAS  Google Scholar 

  10. Bruss MD, Arias EB, Lienhard GE, Cartee GD . Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. Diabetes 2005; 54: 41–50.

    Article  CAS  Google Scholar 

  11. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR . Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes 2006; 55: 1776–1782.

    Article  CAS  Google Scholar 

  12. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28.

    Article  Google Scholar 

  13. Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D . Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 2007; 403: 139–148.

    Article  CAS  Google Scholar 

  14. Momcilovic M, Hong SP, Carlson M . Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem 2006; 281: 25336–25343.

    Article  CAS  Google Scholar 

  15. Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M et al. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci USA 2006; 103: 17378–17383.

    Article  CAS  Google Scholar 

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Acknowledgements

The author wishes to thank Phillip J White for critical reading and editing of the manuscript.

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Authors and Affiliations

  1. Department of Anatomy and Physiology & Lipid Research Unit, Laval University Hospital Research Center, Québec, QC, Canada

    A Marette

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  1. A Marette
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Correspondence to A Marette.

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Marette, A. The AMPK signaling cascade in metabolic regulation: view from the chair. Int J Obes 32 (Suppl 4), S3–S6 (2008). https://doi.org/10.1038/ijo.2008.115

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