The peptide-loading complex is key to the initiation of an immune response that raises killer T cells in vertebrates. Its structure has now been determined, and might provide information that improves immune protection.
References
Blees, A. et al. Nature 551, 525–528 (2017).
Rock, K. L., Reits, E. & Neefjes, J. Trends Immunol. 37, 724–737 (2016).
Ljunggren, H.-G. et al. Nature 346, 476–480 (1990).
Ellgaard, L., McCaul, N., Chatsisvili, A. & Braakman, I. Traffic 17, 615–638 (2016).
Hill, A. et al. Nature 375, 411–415 (1995).
Dong, G., Wearsch, P. A., Peaper, D. R. & Cresswell, P. & Reinisch, K. M. Immunity 30, 21–32 (2009).
Frickel, E.-M. et al. Proc. Natl Acad. Sci. USA 99, 1954–1959 (2002).
Oldham, M. L et al. Nature 529, 537–540 (2016).
Reits, E. A. J., Vos, J. C., Grommé, M & Neefjes, J. Nature 404, 774–778 (2000).
Thomas, C. & Tampé, R. Science https://doi.org/10.1126/science.aao6001 (2017).
Jiang, J. et al. Science https://doi.org/10.1126/science.aao5154 (2017).
Schuren, A. B. C., Costa, A. I. & Wiertz, E. J. H. J. Curr. Opin. Immunol. 40, 43–50 (2016).
Yarchoan, M., Johnson. B. A. III, Lutz, E. R., Laheru, D. A. & Jaffee, E. M. Nature Rev. Cancer 17, 209–222 (2017).
Rights and permissions
About this article
Cite this article
Ploegh, H. Machinery that guides immunity. Nature 551, 442–443 (2017). https://doi.org/10.1038/d41586-017-07268-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/d41586-017-07268-8
- Springer Nature Limited