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Impaired regulatory T cell function in autoimmune diseases: are microRNAs the culprits?

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References

  1. Lin S, Gregory RI . MicroRNA biogenesis pathways in cancer. Nat Rev Cancer 2015; 15: 321–333.

    Article  CAS  Google Scholar 

  2. Dong H, Lei J, Ding L, Wen Y, Ju H, Zhang X . MicroRNA: function, detection, and bioanalysis. Chem Rev 2013; 113: 6207–6233.

    Article  CAS  Google Scholar 

  3. O’Connell RM, Rao DS, Baltimore D . MicroRNA regulation of inflammatory responses. Annu Rev Immunol 2012; 30: 295–312.

    Article  Google Scholar 

  4. Zhu J, Paul WE . CD4 T cells: fates, functions, and faults. Blood 2008; 112: 1557–1569.

    Article  CAS  Google Scholar 

  5. Maddur MS, Sharma M, Hegde P, Stephen-Victor E, Pulendran B, Kaveri SV et al. Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun 2014; 5: Article number 4092.

  6. Josefowicz SZ, Lu LF, Rudensky AY . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30: 531–564.

    Article  CAS  Google Scholar 

  7. Li Z, Li D, Tsun A, Li B . FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol 2015; 12: 558–565.

    Article  Google Scholar 

  8. Sakaguchi S, Miyara M, Costantino CM, Hafler DA . FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10: 490–500.

    Article  CAS  Google Scholar 

  9. Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE . TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006; 108: 253–261.

    Article  CAS  Google Scholar 

  10. Nadkarni S, Mauri C, Ehrenstein MR . Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J Exp Med 2007; 204: 33–39.

    Article  CAS  Google Scholar 

  11. Bayry J, Sibéril S, Triebel F, Tough DF, Kaveri SV . Rescuing the CD4+CD25+ regulatory T cell functions in rheumatoid arthritis by cytokine-targeted monoclonal antibody therapy. Drug Discov Today 2007; 12: 548–552.

    Article  CAS  Google Scholar 

  12. Buckner JH . Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nat Rev Immunol 2010; 10: 849–859.

    Article  CAS  Google Scholar 

  13. Zhou Q, Haupt S, Kreuzer JT, Hammitzsch A, Proft F, Neumann C et al. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis 2015; 74: 1265–1274.

    Article  CAS  Google Scholar 

  14. Zhou L, Park JJ, Zheng Q, Dong Z, Mi Q . MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function. Cell Mol Immunol 2011; 8: 380–387.

    Article  CAS  Google Scholar 

  15. Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S et al. MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. Nat Commun 2015; 6: Article number 7639.

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Acknowledgements

This study was supported by the Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie, and Université Paris Descartes. V.K.S. is a recipient of a fellowship from INSERM under the International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India) scheme.

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Correspondence to Jagadeesh Bayry.

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Sharma, V., Kaveri, S. & Bayry, J. Impaired regulatory T cell function in autoimmune diseases: are microRNAs the culprits?. Cell Mol Immunol 13, 135–137 (2016). https://doi.org/10.1038/cmi.2015.98

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