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Invariant natural killer T cells treated with rapamycin or transforming growth factor-β acquire a regulatory function and suppress T effector lymphocytes

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References

  1. Bendelac A, Savage PB, Teyton L . The biology of NKT cells. Annu Rev Immunol 2007; 25: 297–336 .

    Article  CAS  PubMed  Google Scholar 

  2. Brigl M, Brenner MB . CD1: antigen presentation and T cell function. Annu Rev Immunol 2004; 22: 817–890 .

    Article  CAS  PubMed  Google Scholar 

  3. Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, Wang CR et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 2000; 192: 741–754 .

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L . NKT cells: what’s in a name? Nat Rev Immunol 2004; 4: 231–237 .

    Article  CAS  PubMed  Google Scholar 

  5. Sag D, Krause P, Hedrick CC, Kronenberg M, Wingender G . IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset. J Clin Invest 2014; 124: 3725–3740 .

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hongo D, Tang X, Baker J, Engleman EG, Strober S . Requirement for interactions of natural killer T cells and myeloid-derivedsuppressor cells for transplantation tolerance. Am J Transplant 2014; 14: 2467–2477 .

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Scottà C, Esposito M, Fazekasova H, Fanelli G, Edozie FC, Ali N et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Haematologica 2013; 98: 1291–1299 .

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

All of the authors are thankful to the Central Laboratory for Advanced Diagnostic and Biomedical Research (CLADIBIOR) and Department of Immunoregulation and Immune Intervention for providing the necessary facility to carry out the work. Financial support from the University of Palermo with the International PhD course in Immunopharmacology is also gratefully acknowledged.

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Correspondence to Guido Sireci.

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Guggino, G., Scottà, C., Lombardi, G. et al. Invariant natural killer T cells treated with rapamycin or transforming growth factor-β acquire a regulatory function and suppress T effector lymphocytes. Cell Mol Immunol 14, 392–394 (2017). https://doi.org/10.1038/cmi.2015.20

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  • DOI: https://doi.org/10.1038/cmi.2015.20

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