Abstract
It is generally believed that the expression of a gene is restricted “within the right place and at the right time”. This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig “paradoxically” expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.
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Hu, D., Zheng, H., Liu, H. et al. Immunoglobulin Expression and Its Biological Significance in Cancer Cells. Cell Mol Immunol 5, 319–324 (2008). https://doi.org/10.1038/cmi.2008.39
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DOI: https://doi.org/10.1038/cmi.2008.39
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