Skip to main content

Advertisement

SpringerLink
Log in

Unconditioned unrelated donor bone marrow transplantation for IL7Rα- and Artemis-deficient SCID

  • Letter to the Editor
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

References

  1. Pai SY, Logan BR, Griffith LM, Buckley RH, Parrott RE, Dvorak CC et al. Transplantation outcomes for severe combined immunodeficiency, 2000-2009. N Engl J Med 2014; 371: 434–446.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Buckley R . Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes. Immunol Res 2011; 49: 25–43.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Shearer WT, Dunn E, Notarangelo LD, Dvorak CC, Puck JM, Logan BR et al. Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: The Primary Immune Deficiency Treatment Consortium experience. J Allergy Clin Immunol 2014; 133: 1092–1098.

    Article  PubMed  Google Scholar 

  4. Dvorak C, Hung G, Horn B, Dunn E, Oon C, Cowan M . Megadose CD34(+) cell grafts improve recovery of T cell engraftment but not B cell immunity in patients with severe combined immunodeficiency disease undergoing haplocompatible nonmyeloablative transplantation. Biol Blood Marrow Transplant 2008; 14: 1125–1133.

    Article  CAS  Google Scholar 

  5. Haddad E, Leroy S, Buckley R . B-cell reconstitution for SCID: should a conditioning regimen be used in SCID treatment? J Allergy Clin Immunol 2013; 131: 994–1000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dvorak C, Hassan A, Slatter M, Hönig M, Lankester A, Buckley R et al. Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency. J Allergy Clin Immunol 2014; 134: 935–943.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Schuetz C, Neven B, Dvorak C, Leroy S, Ege M, Pannicke U et al. SCID patients with ARTEMIS versus RAG deficiencies following HCT: increased risk of late toxicity in ARTEMIS deficient SCID. Blood 2013; 123: 281–289.

    Article  PubMed  Google Scholar 

  8. Stauch D, Dernier A, Sarmiento Marchese E, Kunert K, Volk H-D, Pratschke J et al. Targeting of natural killer cells by rabbit antithymocyte globulin and campath-1H: similar effects independent of specificity. PLoS ONE 2009; 4: e4709.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Dvorak C, Horn B, Puck J, Adams S, Veys P, Czechowicz A et al. A trial of alemtuzumab adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency. Pediatr Transplant 2014; 18: 609–616.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Willemsen L, Jol-van der Zijde C, Admiraal R, Putter H, Jansen-Hoogendijk A, Ostaijen-Ten Dam M et al. Impact of serotherapy on immune reconstitution and survival outcomes after stem cell transplantations in children: thymoglobulin versus alemtuzumab. Biol Blood Marrow Transplant 2015; 21: 473–482.

    Article  CAS  PubMed  Google Scholar 

  11. Buckley R, Win C, Moser B, Parrott R, Sajaroff E, Sarzotti-Kelsoe M . Post-transplantation B cell function in different molecular types of SCID. J Clin Immunol 2013; 33: 96–110.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, Benioff Children’s Hospital, University of California, San Francisco, San Francisco, CA, USA

    C C Dvorak, K Patel, J M Puck, J Wahlstrom, M J Dorsey, J Facchino & M J Cowan

  2. Blood and Marrow Transplantation Division, The Center for Cancer & Blood Disorders, Phoenix Children’s Hospital, Phoenix, AZ, USA

    R Adams

Authors
  1. C C Dvorak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J M Puck
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Wahlstrom
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M J Dorsey
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J Facchino
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M J Cowan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C C Dvorak.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dvorak, C., Patel, K., Puck, J. et al. Unconditioned unrelated donor bone marrow transplantation for IL7Rα- and Artemis-deficient SCID. Bone Marrow Transplant 52, 1036–1038 (2017). https://doi.org/10.1038/bmt.2017.74

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2017.74

  • Springer Nature Limited

This article is cited by

Search

Navigation