Skip to main content

Advertisement

SpringerLink
Log in

Fatal intracranial hemorrhage following administration of recombinant thrombomodulin in a patient after cord blood transplantation

  • Letter to the Editor
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

References

  1. Maruyama I . Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation. Thromb Haemost 1999; 82: 718–721.

    Article  CAS  Google Scholar 

  2. Saito H, Maruyama I, Shimazaki S, Yamamoto Y, Aikawa N, Ohno R et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007; 5: 31–41.

    Article  CAS  Google Scholar 

  3. Ikezoe T, Togitani K, Komatsu N, Isaka M, Yokoyama A . Successful treatment of sinusoidal obstructive syndrome after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. Bone Marrow Transplant 2010; 45: 783–785.

    Article  CAS  Google Scholar 

  4. Sakai M, Ikezoe T, Bandobashi K, Togitani K, Yokoyama A . Successful treatment of transplantation-associated thrombotic microangiopathy with recombinant human soluble thrombomodulin. Bone Marrow Transplant 2010; 45: 803–805.

    Article  CAS  Google Scholar 

  5. McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED . Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 1984; 4: 116–122.

    Article  CAS  Google Scholar 

  6. Najima Y, Ohashi K, Miyazawa M, Nakano M, Kobayashi T, Yamashita T et al. Intracranial hemorrhage following allogeneic hematopoietic stem cell transplantation. Am J Hematol 2009; 84: 298–301.

    Article  Google Scholar 

  7. Levi M, Toh CH, Thachil J, Watson HG . Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol 2009; 145: 24–33.

    Article  CAS  Google Scholar 

  8. Ho VT, Revta C, Richardson PG . Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies. Bone Marrow Transplant 2008; 41: 229–237.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan

    M Tsubokura, T Yamashita, L Inagaki, T Kobayashi, K Kakihana, S Wakabayashi, K Ohashi, H Sakamaki & H Akiyama

  2. Department of Hematology and Respiratory Medicine, Kochi University, Kochi, Japan

    T Ikezoe

  3. Third Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

    H Asakura

  4. Laboratory Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    T Koyama

  5. Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    T Tanimoto

  6. Division of Social Communication System for Advanced Clinical Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    M Kami

Authors
  1. M Tsubokura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L Inagaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K Kakihana
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S Wakabayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K Ohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T Ikezoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H Asakura
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T Koyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. T Tanimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M Kami
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. H Sakamaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. H Akiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Tsubokura.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tsubokura, M., Yamashita, T., Inagaki, L. et al. Fatal intracranial hemorrhage following administration of recombinant thrombomodulin in a patient after cord blood transplantation. Bone Marrow Transplant 46, 1030–1031 (2011). https://doi.org/10.1038/bmt.2010.229

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2010.229

  • Springer Nature Limited

This article is cited by

Search

Navigation