Skip to main content
SpringerLink
Log in

Cell Procurement

Efficient mobilization of PBSC with vinorelbine/G-CSF in patients with malignant lymphoma

  • Original Article
  • Published:
Bone Marrow Transplantation Submit manuscript

Abstract

High-dose chemotherapy (HDT) and hematopoietic SCT are effective in patients with relapsing or refractory malignant lymphoma. Collection of sufficient numbers of stem cells is a prerequisite for such a therapy. In a pilot trial, we evaluated the feasibility of stem cell mobilization with vinorelbine/G-CSF in patients with lymphoma, a regimen allowing precise timing and harvesting of sufficient stem cells in myeloma patients. Forty-five patients with lymphoma received vinorelbine 35 mg/m2 i.v. on day 1 and G-CSF 10 μg/kg/day s.c., divided in two daily doses from day 4 until collection. Stem cell collection was successfully performed in 43 patients (96%) with a median of 3.6 × 106 CD34+ cells/kg (range: 1.4–16) in the collected product. In 28 patients (62%), the first stem cell apheresis was performed on day 8, and for 28 patients a sufficient stem cell yield was reached with one apheresis only. All 43 patients underwent high-dose chemotherapy with BEAM and auto-SCT with hematological recovery on time and without unexpected toxicity. In conclusion, vinorelbine/G-CSF allows accurate timing and safe harvesting of sufficient stem cells in patients with malignant lymphoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Milpied N, Deconinck E, Gaillard F, Delwail V, Foussard C, Berthou C et al. Initial treatment of aggressive lymphoma with high-dose chemotherapy and autologous stem-cell support. N Engl J Med 2004; 350: 1287–1295.

    Article  CAS  Google Scholar 

  2. Philip T, Guglielmi C, Hagenbeek A, Somers R, Van Der Lelie H, Bron D et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med 1995; 333: 1540–1545.

    Article  CAS  Google Scholar 

  3. Goldschmidt H, Hegenbart U, Haas R, Hunstein W . Mobilization of peripheral blood progenitor cells with high-dose cyclophosphamide (4 or 7 g/m2) and granulocyte colony-stimulating factor in patients with multiple myeloma. Bone Marrow Transplant 1996; 17: 691–697.

    CAS  PubMed  Google Scholar 

  4. Haas R, Mohle R, Fruhauf S, Goldschmidt H, Witt B, Flentje M et al. Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma. Blood 1994; 83: 3787–3794.

    CAS  PubMed  Google Scholar 

  5. Koc ON, Gerson SL, Cooper BW, Laughlin M, Meyerson H, Kutteh L et al. Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF. J Clin Oncol 2000; 18: 1824–1830.

    Article  CAS  Google Scholar 

  6. Desikan KR, Barlogie B, Jagannath S, Vesole DH, Siegel D, Fassas A et al. Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma. J Clin Oncol 1998; 16: 1547–1553.

    Article  CAS  Google Scholar 

  7. Bargetzi MJ, Passweg J, Baertschi E, Schoenenberger A, Gwerder C, Tichelli A et al. Mobilization of peripheral blood progenitor cells with vinorelbine and granulocyte colony-stimulating factor in multiple myeloma patients is reliable and cost effective. Bone Marrow Transplant 2003; 31: 99–103.

    Article  CAS  Google Scholar 

  8. Magagnoli M, Sarina B, Balzarotti M, Castagna L, Timofeeva I, Nozza A et al. Mobilizing potential of ifosfamide/vinorelbine-based chemotherapy in pretreated malignant lymphoma. Bone Marrow Transplant 2001; 28: 923–927.

    Article  CAS  Google Scholar 

  9. Devizzi L, Santoro A, Bonfante V, Viviani S, Bonadonna G . Vinorelbine: a new promising drug in Hodgkin's disease. Leuk Lymphoma 1996; 22: 409–414.

    Article  CAS  Google Scholar 

  10. Rule S, Tighe M, Davies S, Johnson S . Vinorelbine in the treatment of lymphoma. Hematol Oncol 1998; 16: 101–105.

    Article  CAS  Google Scholar 

  11. Aapro MS, Harper P, Johnson SA, Vermorken JB . Developments in cytotoxic chemotherapy: advances in treatment utilising vinorelbine. Crit Rev Oncol Hematol 2001; 40: 251–263.

    Article  CAS  Google Scholar 

  12. Gatama JW, Keeney M, Sutherland DR . Enumeration of CD34+ hematopoietic and progenitor cells. Curr Prot Cytometry 1999; 6: 1–22.

    Google Scholar 

  13. Moskowitz CH, Glassman JR, Wuest D, Maslak P, Reich L, Gucciardo A et al. Factors affecting mobilization of peripheral blood progenitor cells in patients with lymphoma. Clin Cancer Res 1998; 4: 311–316.

    CAS  PubMed  Google Scholar 

  14. Seyfarth B, Josting A, Dreyling M, Schmitz N . Relapse in common lymphoma subtypes: salvage treatment options for follicular lymphoma, diffuse large cell lymphoma and Hodgkin disease. Br J Haematol 2006; 133: 3–18.

    Article  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge Mrs Hannelore Oesterreicher for excellent technical assistance.

Author information

Authors and Affiliations

  1. Center of Oncology/Hematology and Transfusion Medicine, Kantonsspital Aarau, Aarau, Switzerland

    M Heizmann, A C O'Meara, P R Moosmann, M Zuberbühler, P Fernandez, J Burger, M Wernli & M J Bargetzi

  2. Center of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland

    I A F M Heijnen, P Fernandez & A Huber

Authors
  1. M Heizmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A C O'Meara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P R Moosmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I A F M Heijnen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Zuberbühler
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P Fernandez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J Burger
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A Huber
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M Wernli
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M J Bargetzi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Heizmann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heizmann, M., O'Meara, A., Moosmann, P. et al. Efficient mobilization of PBSC with vinorelbine/G-CSF in patients with malignant lymphoma. Bone Marrow Transplant 44, 75–79 (2009). https://doi.org/10.1038/bmt.2008.434

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2008.434

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation