Abstract
Helicobacter pylori (H. pylori) infection and intestinal metaplasia (IM) are each associated with an increased risk of gastric cancer (GC). To explore further the influences of H. pylori and IM on GC, H. pylori and subtypes of IM were evaluated in 135 sex and age-matched case and control pairs. Odds ratios (ORs) with 95% confidence intervals of developing GC were calculated for each risk factor using multiple logistic regression analysis. ORs for H. pylori infection and IM were 2.43 (1.29-4.65) and 4.59 (2.58-8.16), respectively, and those for different IM subtypes gave values of 0.82 (0.28-2.36) for type I, 2.03 (0.95-4.34) for type II and 39.75 (14.34-110.2) for type III. Stratification analysis by histological subtype and stage of GC showed a particularly high OR for IM in intestinal type (12.8, 4.73-34.83) and early GC (6.40, 2.25-18.18). Our data indicate that both H. pylori and IM are related to GC risk. Type III IM is a more specific marker of premalignancy, with relevance, in particular, to the early and intestinal type of GC.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wu, MS., Shun, CT., Lee, WC. et al. Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia. Br J Cancer 78, 125–128 (1998). https://doi.org/10.1038/bjc.1998.453
Issue Date:
DOI: https://doi.org/10.1038/bjc.1998.453
- Springer Nature Limited
This article is cited by
-
The risk of diffuse-type gastric cancer following diagnosis with gastric precancerous lesions: a systematic review and meta-analysis
Cancer Causes & Control (2022)
-
A meta-analysis and systematic review on subtypes of gastric intestinal metaplasia and neoplasia risk
Cancer Cell International (2021)
-
CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer
Modern Pathology (2007)
-
Antigen MG7 in gastric cancer and gastric precancerous lesions
Chinese Journal of Cancer Research (2004)