Abstract
Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs, 141 cases (75%) showed expression of cyclin A. Patients with cyclin A-positive carcinomas had significantly shorter median survival times than patients with cyclin A-negative carcinomas (79 vs 129 weeks, P = 0.045). Similar results were obtained with more homogeneous groups of patients: patients with only T3 tumours, patients with epidermoid carcinomas and patients with lymph node involvement. The clinical parameters (age, stage, histology, extent of tumour size, lymph node involvement) had no influence on expression of cyclin A. A direct correlation between cyclin A and the proportion of S-phase cells (P = 0.08) and an inverse relationship between cyclin A and the proportion of G0/G1-phase cells (P = 0.04) were found. Furthermore, a significant correlation between the expression of cyclin A and the response of NSCLC to doxorubicin in vitro was detected (P = 0.026).
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Volm, M., Koomägi, R., Mattern, J. et al. Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas. Br J Cancer 75, 1774–1778 (1997). https://doi.org/10.1038/bjc.1997.302
Issue Date:
DOI: https://doi.org/10.1038/bjc.1997.302
- Springer Nature Limited
This article is cited by
-
Identification of Core Genes and Pathways in Medulloblastoma by Integrated Bioinformatics Analysis
Journal of Molecular Neuroscience (2020)
-
Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Tumor Biology (2014)
-
Cyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer
British Journal of Cancer (2005)
-
Expression of cyclins, p53, and Ki-67 in cervical squamous cell carcinomas: overexpression of cyclin A is a poor prognostic factor in stage Ib and II disease
Virchows Archiv (2005)
-
Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis
Oncogene (2002)