Abstract
Gradient-recalled echo magnetic resonance imaging (GRE MRI), which gives information on blood flow and oxygenation changes (Robinson SP, Howe FA, Griffiths JR 1995, Int J Radiat Oncol Biol Phys 33: 855), was used to observe the responses of six rodent tumour models to carbogen breathing. In one transplanted rat tumour, the Morris hepatoma 9618a, and a chemically induced rat tumour, the MNU-induced mammary adenocarcinoma, there were marked image intensity increases, similar to those previously observed in the rat GH3 prolactinoma. In contrast, the rat Walker carcinosarcoma showed no response. In two mouse tumours, the RIF-1 fibrosarcoma and the human xenograft HT29, carbogen breathing induced a transient fall in signal intensity that reversed spontaneously within a few minutes. The rat GH3 prolactinoma was xenografted into nude mice, and an increase in image intensity was found in response to carbogen, suggesting that any effects that carbogen may have had on the host were not significant determinants of the tumour response. The increases in GRE image intensity of the MNU, H9618a and GH3 tumours during carbogen breathing are consistent with increases in tumour oxygenation and blood flow, whereas the responses of the RIF-1 and HT29 tumours may be the result of a transient steal effect followed by homeostatic correction.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Robinson, S., Rodrigues, L., Ojugo, A. et al. The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging. Br J Cancer 75, 1000–1006 (1997). https://doi.org/10.1038/bjc.1997.172
Issue Date:
DOI: https://doi.org/10.1038/bjc.1997.172
- Springer Nature Limited
This article is cited by
-
Dependency of the blood oxygen level dependent-response to hyperoxic challenges on the order of gas administration in intracranial malignancies
Neuroradiology (2019)
-
Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans
British Journal of Cancer (2009)
-
Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours
Cancer Chemotherapy and Pharmacology (2005)
-
Relationship between tumour growth rate and carbogen-based functional MRI for a chemically induced HCC in mice
Magnetic Resonance Materials in Physics, Biology and Medicine (2004)
-
Applications of Magnetic Resonance in Model Systems: Tumor Biology and Physiology
Neoplasia (2000)