Abstract
Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer.
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Agrez, M., Bates, R., Mitchell, D. et al. Multiplicity of fibronectin-binding αV integrin receptors in colorectal cancer. Br J Cancer 73, 887–892 (1996). https://doi.org/10.1038/bjc.1996.158
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DOI: https://doi.org/10.1038/bjc.1996.158
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