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Prevention of metastasis from mouse mammary carcinomas with liposomes carrying doxorubicin

  • Experimental Oncology
  • Published:
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Abstract

Weekly treatments with doxorubicin encapsulated in long circulating, sterically stabilised liposomes (DOX-SL) reduced the incidence of metastases from primary mammary carcinoma from 24 of 47 untreated mice to 3 of 23 treated mice. Toxic side-effects were limited to minor, transient weight losses.

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Authors and Affiliations

  1. Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, 14263, NY, USA

    J Vaage

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  1. J Vaage
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  2. D Donovan
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  3. T Loftus
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  4. P Working
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Vaage, J., Donovan, D., Loftus, T. et al. Prevention of metastasis from mouse mammary carcinomas with liposomes carrying doxorubicin. Br J Cancer 72, 1074–1075 (1995). https://doi.org/10.1038/bjc.1995.467

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  • DOI: https://doi.org/10.1038/bjc.1995.467

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