Abstract
The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.
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Woodburn, K., Hill, J., Stylli, S. et al. Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy. Br J Cancer 70, 398–400 (1994). https://doi.org/10.1038/bjc.1994.316
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DOI: https://doi.org/10.1038/bjc.1994.316
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