Abstract
The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Additional information
A project sponsored by the British Breast Grotup.
Rights and permissions
About this article
Cite this article
Roberts, M., Rubens, R., King, R. et al. Oestrogen receptors and the response to endocrine therapy in advanced breast cancer. Br J Cancer 38, 431–436 (1978). https://doi.org/10.1038/bjc.1978.225
Issue Date:
DOI: https://doi.org/10.1038/bjc.1978.225
- Springer Nature Limited
This article is cited by
-
Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status
Virchows Archiv A Pathological Anatomy and Histopathology (1992)
-
Immunocytochemical reactivity of breast cancer tissue with antibodies to neuron-specific enolase and an adenocarcinoma-associated glycolipid antigen
Virchows Archiv A Pathological Anatomy and Histopathology (1989)
-
Oestrogen receptor activity in breast cancer detected at a prevalence screening examination
Breast Cancer Research and Treatment (1987)
-
Cellularity and the quantitation of estrogen receptors
Breast Cancer Research and Treatment (1982)
-
The biology and physiology of ‘Nolvadex’ (tamoxifen) in the treatment of breast cancer
Breast Cancer Research and Treatment (1982)