Abstract
Pre-operative X-irradiation of s.c. implanted first-generation mammary tumours in C3H mice, using either 500 rad or two fractions of 350 rad, produced no improvement in the success of surgery in causing local control or in reduction of distant metastases. The metastasis rate was just significantly higher after the two-fraction treatment of the implanted tumour than after surgical removal alone. The results are in agreement with previously published results on carcinomas and a sarcoma but contrast with those for murine lymphomas.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Sheldon, P., Fowler, J. The effect of low-dose pre-operative X-irradiation of implanted mouse mammary carcinomas on local recurrence and metastasis. Br J Cancer 34, 401–407 (1976). https://doi.org/10.1038/bjc.1976.183
Issue Date:
DOI: https://doi.org/10.1038/bjc.1976.183
- Springer Nature Limited
This article is cited by
-
Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?
Nature Reviews Clinical Oncology (2017)
-
Effects of radiation on metastasis and tumor cell migration
Cellular and Molecular Life Sciences (2016)
-
Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation
British Journal of Cancer (2004)
-
Radiation enhancement of metastasis: a review
Clinical & Experimental Metastasis (1991)